Time and Energy, Exploring Trajectory Options Between Nodes in Earth-Moon Space

The Global Exploration Roadmap (GER) was released by the International Space Exploration Coordination Group (ISECG) in September of 2011. It describes mission scenarios that begin with the International Space Station and utilize it to demonstrate necessary technologies and capabilities prior to deployment of systems into Earth-Moon space. Deployment of these systems is an intermediate step in preparation for more complex deep space missions to near-Earth asteroids and eventually Mars. In one of the scenarios described in the GER, "Asteroid Next", there are activities that occur in Earth-Moon space at one of the Earth-Moon Lagrange (libration) points. In this regard, the authors examine the possible role of an intermediate staging point in an effort to illuminate potential trajectory options for conducting missions in Earth-Moon space of increasing duration, ultimately leading to deep space missions. This paper will describe several options for transits between Low Earth Orbit (LEO) and the libration points, transits between libration points, and transits between the libration points and interplanetary trajectories. The solution space provided will be constrained by selected orbital mechanics design techniques and physical characteristics of hardware to be used in both crewed missions and uncrewed missions. The relationships between time and energy required to transfer hardware between these locations will provide a better understanding of the potential trade-offs mission planners could consider in the development of capabilities, individual missions, and mission series in the context of the ISECG GER

HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1

An estimated 10–20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), with endemic areas of infection in Japan, Australia, the Caribbean, and Africa. HTLV-1 is the causative agent of adult T cell leukemia (ATL) and HTLV-1 associated myopathy/tropic spastic paraparesis (HAM/TSP). HTLV-1 expresses several regulatory and accessory genes that function at different stages of the virus life cycle. The regulatory gene Tax-1 is required for efficient virus replication, as it drives transcription of viral gene products, and has also been demonstrated to play a key role in the pathogenesis of the virus. Several studies have identified a PDZ binding motif (PBM) at the carboxyl terminus of Tax-1 and demonstrated the importance of this domain for HTLV-1 induced cellular transformation. Using a mass spectrometry-based proteomics approach we identified sorting nexin 27 (SNX27) as a novel interacting partner of Tax-1. Further, we demonstrated that their interaction is mediated by the Tax-1 PBM and SNX27 PDZ domains. SNX27 has been shown to promote the plasma membrane localization of glucose transport 1 (GLUT1), one of the receptor molecules of the HTLV-1 virus, and the receptor molecule required for HTLV-1 fusion and entry. We postulated that Tax-1 alters GLUT1 localization via its interaction with SNX27. We demonstrate that over expression of Tax-1 in cells causes a reduction of GLUT1 on the plasma membrane. Furthermore, we show that knockdown of SNX27 results in increased virion release and decreased HTLV-1 infectivity. Collectively, we demonstrate the first known mechanism by which HTLV-1 regulates a receptor molecule post-infection.</div

A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies

Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies

Watseka Pavilion

Students will design an open-air pavilion for the city park in Watseka.  The design will include architectural and structural design.  Substantial completion of design documents is required

Agreement on Access and Benefit-sharing for Academic Research: A toolbox for drafting Mutually Agreed Terms for access to Genetic Resources and to Associated Traditional Knowledge and Benefit-sharing

This manual contains a set of model clauses that enables users and providers of genetic resources and associated traditional knowledge to set up a legal contract that is adapted to the individual academic research situation. If mutually negotiated and agreed upon by the involved partners this agreement can yield a “Mutually Agreed Terms” ABS contract

Senior Recital: Jacob Martinez, Saxophone

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Music Education. Mr. Martinez studies saxophone with Luke Weathington.https://digitalcommons.kennesaw.edu/musicprograms/2285/thumbnail.jp

HIV Risk Knowledge among Hispanic Adults in a U.S. – Mexico Border Community: Opportunities for Sexual Health Promotion and Education

Background and Purpose: Hispanics experience a disproportionate burden of chronic disease, including HIV/AIDS. Community-level data regarding HIV risk and transmission are vital to effectively respond to health disparities in unique, high-risk populations. This study described HIV risk behavior knowledge among Hispanics in El Paso, Texas, in order to contribute to culturally and linguistically appropriate services for clinical and community settings in this U.S.-Mexico border community. Specifically, this project highlights misconceptions and gaps in HIV risk knowledge in two Mexican-American adult samples: (1) 103 men recruited primarily through agencies providing HIV-related medical and social services, and (2) 98 women recruited primarily through events hosted at a local community center. Methods: Data were gathered through structured interviews with participants as part of a larger study of HIV risk factors. Results: Less than 20% of men and 5% of women answered all 12 knowledge items correctly. Conclusion: This study builds on previous research identifying gaps in HIV knowledge by prioritizing two different at-risk populations in a U.S.- Mexico border community, where sociodemographic factors such as poverty, stigma, and limited access to healthcare services may contribute to increased HIV risk

Senior Recital: Jonathan Swann, saxophone

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Music Education. Mr. Swann studies saxophone with Sam Skelton.https://digitalcommons.kennesaw.edu/musicprograms/2219/thumbnail.jp